Kinetica

Kinetica Model Libraries

Thermo's Kinetica model library collection features many models of biological, pharmacokinetic and pharmacodynamic systems created as Kinetica templates. The models cover Dr. William Jusko's pharmacodynamic models and the pharmacokinetic and pharmacodynamic models in Dr. Johan Gabrielsson's book 'Pharmacokinetic and Pharmacodynamic Data Analysis'.

Pharmacokinetic Models

• One Compartment model with First Order Absorption using Macro Constants (kdb)
• One Compartment model with First Order Absorption using Micro Constants (kdb)
• One Compartment IV Infusion model using Macro Constants (kdb)
• One Compartment IV Infusion model using Micro Constants (kdb)
• One Compartment model with Zero Order Absorption using Macro Constants (kdb)
• One Compartment model with Zero Order Absorption using Micro Constants (kdb)

Jusko's Pharmacodynamic Models

• Cell Proliferation Linear Irreversible Inactivation (html/kdb)
• Cell Proliferation Nonlinear Irreversible Inactivation (html/kdb)
• Indirect Response – Inhibition of Production Rate for single dose
• Indirect Response – Inhibition of Production Rate for 2 doses
• Indirect Response – Inhibition of Dissipation Process for 2 doses
• Indirect Response – Stimulation of Production Rate for 2 doses
• Indirect Response – Stimulation of Dissipation Process for 2 doses
• Signal Transduction (html/kbd)
• Turnover Model with Irreversible Linear Inactivation (html/kbd)
• Turnover Model with Irreversible Nonlinear Inactivation(html/kbd)

Gabrielsson's Pharmacokinetic Models

• Discussion of Models and Output (pdf)
• Download all pharmacokinetic models (zip)

Gabrielsson's Pharmacodynamic Models

• Download all pharmacodynamic models (zip)